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Hypopigmented common blue nevus

S Carr1, J See, B Wilkinson

  • 1Skin and Cancer Foundation Australia, Darlinghurst, N. S. W., Australia.

Journal of Cutaneous Pathology
|October 23, 1997
PubMed
Summary
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Hypopigmented blue nevus (HBN) is a rare variant of common blue nevus with minimal pigment. The HMB-45 stain is a useful diagnostic tool, showing uniform positivity in HBN cases.

Area of Science:

  • Dermatopathology
  • Oncology
  • Immunohistochemistry

Background:

  • Blue nevus is a benign dermal melanocyte lesion with variants like common, cellular, and combined types.
  • Hypopigmented blue nevus (HBN) presents with minimal melanin pigment, posing diagnostic challenges.
  • Distinguishing HBN from other dermal lesions is crucial for accurate diagnosis and treatment.

Purpose of the Study:

  • To describe 9 cases of hypopigmented blue nevus (HBN).
  • To evaluate the diagnostic utility of the HMB-45 immunoperoxidase stain in HBN.
  • To differentiate HBN from histologically similar lesions.

Main Methods:

  • Case series of 9 hypopigmented blue nevus patients.
  • Histopathological examination of HBN and differential diagnoses.

Related Experiment Videos

  • Immunohistochemical staining using HMB-45 antibody.

    • Main Results:

    • All 9 HBN cases showed uniform HMB-45 positivity.
    • Other dermal lesions (intradermal nevus, dermatofibroma, neurofibroma, scar, melanoma) showed negative or focal HMB-45 positivity.
    • HBN shares similar physical distribution and age range with common blue nevus.

    Conclusions:

    • HMB-45 stain is a valuable tool for diagnosing HBN.
    • HBN is a distinct variant of common blue nevus, not a degenerative change.
    • HBN predominantly affects young adults, suggesting a developmental origin.