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Permeability of contrast media through hemodialysis membrane
T Furukawa1, J Ueda, K Higashino
1Department of Radiology, Sumitomo Hospital, Osaka, Japan.
Purpose:
To compare the permeability of 10 contrast media (CM) through the hemodialysis membrane.
Material And Methods:
An experimental model was constructed from clinical hemodialysis equipment. The 10 CM that were used were: diatrizoate, iothalamate, iopamidol, iohexol, iopromide, ioversol, iomeprol, ioxaglate, iodixanol and iotrolan. They were dissolved into the dialysate. Each solution ran into the blood circuit of the dialyzer at a rate of 200 ml/min and into the dialysate circuit of the dialysis machine at a rate of 500 ml/min. Permeability was expressed as clearance, calculated from the iodine concentration at the afferent and efferent lines of the dialyzer, and from the blood-flow rate.
Results:
The clearance of all the monomeric CM was superior to that of all the dimeric CM. Values of clearance and molecular weight correlated well.
Conclusion:
The molecular weight of a contrast medium is the main factor that influences the efficiency of CM removal by hemodialysis.