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Mesial temporal spikes interfere with working memory

G L Krauss1, M Summerfield, J Brandt

  • 1Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.

Neurology
|October 27, 1997
PubMed
Summary
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Mesial temporal spikes, often linked to epilepsy, can disrupt working memory. This study found that these spikes negatively impact verbal and visuospatial recall in patients with epilepsy.

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Epileptology

Background:

  • The hippocampus and mesial temporal structures are crucial for long-term memory.
  • These brain regions are also common seizure foci in epilepsy.
  • Emerging evidence suggests their role in working memory processes.

Purpose of the Study:

  • To investigate the impact of mesial temporal spikes on working memory accuracy.
  • To differentiate the effects on verbal versus visuospatial working memory.
  • To assess if spike detection on extracranial recordings correlates with working memory deficits.

Main Methods:

  • Eight patients with intractable epilepsy and bilateral depth electrodes were studied.
  • Working memory performance (verbal and visuospatial) was assessed during mesial temporal spiking and in its absence.

Related Experiment Videos

  • Spike activity was monitored via intracranial recordings.

    • Main Results:

    • Six out of eight patients showed declines in working memory performance during mesial temporal spiking.
    • The most significant disruptions in spatial and verbal recall occurred with left hippocampal spikes (p = 0.019).
    • Overall working memory accuracy decreased by an average of 6% during spike trials.

    Conclusions:

    • Mesial temporal spikes are associated with working memory impairments in epilepsy patients.
    • The severity of impairment may depend on the location of the spikes (e.g., left hippocampus).
    • Intracranial monitoring is necessary to detect these subtle effects, as extracranial recordings may miss them.