Related Experiment Video
Updated: Aug 10, 2026
Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
Published on: December 8, 2013
Comparison of atherosclerosis in alaska Natives and nonnatives
W P Newman1, J P Middaugh, M A Guzman
1Department of Pathology, Louisiana State University School of Medicine, New Orleans 70112, USA.
Objective:
To test the hypothesis that Alaska Natives have fewer atherosclerotic lesions in the coronary arteries and aorta than nonnative Alaska residents.
Design:
Systematic standardized collection and evaluation of coronary arteries and aortas collected at autopsy.
Setting:
Forensic autopsy service in Alaska.
Subjects:
One hundred thirty Alaska Natives and 115 Alaska nonnatives who underwent forensic autopsy between February 1989 and December 1993.
Intervention:
None.
Main Outcome Measures:
Prevalence and extent of atherosclerotic lesions in the aortas and coronary arteries in both populations studied.
Results:
Alaska Natives had significantly lower prevalence and extent of raised atherosclerotic lesions in the abdominal aorta and coronary arteries than nonnative Alaska residents.
Conclusions:
Differences in coronary heart disease mortality between Alaska Natives and nonnatives are, at least in part, the result of fewer atherosclerotic lesions in Alaska Natives.
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