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Cell migration in the developing chick diencephalon

J A Golden1, J C Zitz, K McFadden

  • 1Department of Pathology, Children's Hospital of Philadelphia and the University of Pennsylvania School of Medicine, 19104, USA. goldenj@mail.med.upenn.edu

Development (Cambridge, England)
|October 28, 1997
PubMed
Summary
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Newly hatched chick diencephalon development reveals that radial glia guide early cell migration. Later, tangential migration occurs outside the ventricular zone, utilizing axonal tracts for guidance.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Migration

Background:

  • Previous studies showed widespread dispersion of retrovirally marked clones in the mature chick diencephalon.
  • Understanding the migration routes is crucial for comprehending brain development.

Purpose of the Study:

  • To define the specific migration routes of neuronal precursors in the developing chick diencephalon.
  • To investigate the mechanisms underlying tangential migration beyond radial glial guidance.

Main Methods:

  • Retroviral labeling of embryonic chick diencephalon cells at stages 10-14.
  • Analysis of clone dispersion and cell migration patterns at embryonic days 4-7.
  • Utilizing PCR, sequencing, DiI tracing, immunohistochemistry, and electron microscopy.

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Main Results:

  • Initially, clones formed radial columns within the neuroepithelium's ventricular zone.
  • Tangential migration initiated outside the ventricular zone around embryonic day 5.
  • By embryonic days 6-7, over 50% of clones exhibited non-radial migration along axonal tracts.

Conclusions:

  • Chick diencephalon development involves both radial and tangential migration pathways.
  • Non-radial migration initiates outside the ventricular zone and is supported by axonal tracts.
  • These findings highlight alternative migration routes independent of radial glia.