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Hepatitis C virus nonstructural region 5A protein is a potent transcriptional activator
N Kato1, K H Lan, S K Ono-Nita
1Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan. kato-2im@h.u-tokyo.ac.jp
Journal of Virology
|October 29, 1997
Abstract:
The hepatitis C virus (HCV) nonstructural region 5A (NS5A) protein, without its 146 amino-terminal amino acids and fused to the DNA-binding domain of GAL4, strongly activates transcription in yeast and human hepatoma cells. Transcriptional activation by the HCV NS5A protein may play a role in viral replication and hepatocarcinogenesis.