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The craniofacial complex in 47,XYY males

M Grön1, K Pietilä, L Alvesalo

  • 1Department of Oral Development and Orthodontics, University of Oulu, Finland.

Archives of Oral Biology
|August 1, 1997
PubMed
Summary

Males with 47,XYY syndrome exhibit larger craniofacial dimensions compared to controls. These differences, including facial height and cranial base, suggest genetic influences on skeletal development.

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Area of Science:

  • Genetics
  • Anthropology
  • Human Biology

Background:

  • The 47,XYY karyotype is a chromosomal abnormality in males.
  • Previous research indicates potential effects of chromosomal variations on physical development.

Purpose of the Study:

  • To investigate craniofacial morphology in adult males with the 47,XYY karyotype.
  • To compare craniofacial dimensions and proportions between 47,XYY males and control groups.

Main Methods:

  • Lateral cephalograms of eight adult Finnish 47,XYY males were analyzed.
  • Craniofacial linear and angular measurements were compared with population male/female controls and relatives.

Main Results:

  • 47,XYY males showed significantly larger craniofacial dimensions than controls.
  • Specific differences included increased lower facial height, posterior mandibular rotation, tendency to bimaxillary protrusion, longer cranial base, and a smaller cranial base angle.
  • The foramen magnum was smaller in the sagittal plane in 47,XYY males.

Conclusions:

  • Supernumerary Y chromosome genes in 47,XYY males influence craniofacial dimensions.
  • These genetic factors lead to larger skeletal features without major alterations in proportions or plane angles.
  • The observed craniofacial pattern aligns with other documented physical variations in 47,XYY individuals.

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