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Related Experiment Videos

Inhibitory interactions between perigeniculate GABAergic neurons

M V Sanchez-Vives1, T Bal, D A McCormick

  • 1Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|November 14, 1997
PubMed
Summary
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Perigeniculate nucleus (PGN) neurons mutually inhibit each other via GABAergic signaling, controlling their excitability. This PGN to PGN inhibition creates a center-surround mechanism within the dorsal lateral geniculate nucleus (LGNd).

Area of Science:

  • Neuroscience
  • Neurophysiology
  • GABAergic signaling

Background:

  • Perigeniculate nucleus (PGN) neurons form an inhibitory network influencing thalamocortical neurons in the dorsal lateral geniculate nucleus (LGNd).
  • The precise mechanisms of PGN-to-PGN inhibition and its functional consequences remain incompletely understood.

Purpose of the Study:

  • To investigate the inhibitory interactions between perigeniculate nucleus (PGN) neurons.
  • To elucidate the receptor subtypes involved in PGN-to-PGN inhibition.
  • To explore the functional impact of PGN self-inhibition on neuronal excitability and LGNd circuitry.

Main Methods:

  • Intracellular recordings in vitro from PGN neurons during spontaneous spindle wave activity.
  • Local glutamate application to evoke synaptic responses in neighboring PGN neurons.

Related Experiment Videos

  • Pharmacological manipulation using GABA receptor antagonists (bicuculline, picrotoxin) and agonists (muscimol, baclofen).
  • Anatomical analysis of biocytin-filled PGN neuron axon collaterals.

    • Main Results:

    • Glutamate stimulation evoked fast inhibitory postsynaptic potentials (IPSPs) in neighboring PGN neurons, mediated by GABAA receptors (reversal potential -77 mV).
    • A subset of PGN neurons (40%) also exhibited slow IPSPs mediated by GABAB receptors upon GABAA receptor blockade.
    • PGN neurons possess functional GABAA and GABAB receptors, and their axons form local collaterals within the PGN, supporting PGN-to-PGN inhibition.
    • Inhibition between PGN neurons reduced or abolished low-threshold calcium spikes and tonic discharge.

    Conclusions:

    • Mutual inhibition among PGN neurons, mediated by both GABAA and GABAB receptors, tightly controls their excitability.
    • This PGN self-inhibition generates a 'center-surround' inhibitory/disinhibitory circuit within the LGNd, impacting thalamic function.
    • The findings reveal a novel circuit motif for regulating information flow through the LGNd.