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Infrared and Raman vibrational optical activity: theoretical and experimental aspects
1Department of Chemistry, Syracuse University, New York 13244-4100, USA. LNAFIE@SYR.EDU
Annual Review of Physical Chemistry
|January 1, 1997
Summary
Vibrational optical activity (VOA), including VCD and ROA, has seen significant theoretical and instrumental advancements over the last decade. These developments enhance the application of VOA for analyzing molecular chirality in biological and pharmaceutical research.
Area of Science:
- Spectroscopy
- Physical Chemistry
- Biophysics
Background:
- Vibrational optical activity (VOA) encompasses vibrational circular dichroism (VCD) and Raman optical activity (ROA).
- These techniques probe molecular chirality, crucial in stereochemistry and biological systems.
- Progress in VOA is driven by theoretical and instrumental innovations.
Purpose of the Study:
- To review advances in VOA over the past decade.
- To highlight theoretical and instrumental progress in VCD and ROA.
- To survey applications of VOA in stereochemical and biological problems.
Main Methods:
- Review of theoretical developments in VOA calculations.
- Analysis of instrumental improvements in VCD and ROA.
- Survey of experimental applications in stereochemistry and biology.
Main Results:
- Significant improvements in ab initio calculations of VOA intensities for VCD.
- Enhanced quality of step-scan Fourier transform instrumentation for VCD.
- Dramatic progress in theoretical formulation and high-throughput instrumentation for ROA.
- Broadened applications of VOA to major biological and pharmaceutical molecules.
Conclusions:
- VOA techniques, VCD and ROA, have advanced significantly in theory and instrumentation.
- These advances enable new experimental capabilities for chiral molecule analysis.
- VOA is increasingly important for diagnosing and controlling molecular chirality in research and industry.