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Soluble intercellular adhesion molecule-1 in sera from patients with chronic hepatitis C undergoing interferon
A M Sonnante1, R Cozzolongo, R Cuppone
1Laboratorio di Patologia Clinica, Ospedale S. de Bellis, IRCCS Castellana-Grotte (BA), Italy.
Archives of Virology
|January 1, 1997
Abstract:
To study the influence of interferon therapy on soluble intercellular adhesion molecule-1 we measured sICAM-1 levels in 22 patients with type C chronic hepatitis treated with interferon. We also studied 9 healthy subjects as control group. The results showed statistically significant higher levels of sICAM-1 in patients with liver disease than in the controls. The sICAM-1 baseline levels were similar in patients with chronic active hepatitis or cirrhosis but, during therapy, these levels decreased only in patients with chronic hepatitis. After IFN withdrawal sICAM-1 levels rebounded to initial values.