Hyperthermia following self-stimulation of the median raphe in the rat

Electrical self-stimulation (SS) in the median raphé of the rat but not in the locus coeruleus resulted in a dramatic rise of body temperature. This hyperthermia was facilitated by pretreatment with a inhibitor of serotonin uptake. The functional significance of the hyperthermia elicited by stimulation of the media raphé was discussed on the basis of the relationship between SS and primary reinforcers.