Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

CD6-ligand interactions: a paradigm for SRCR domain function?

A Aruffo1, M A Bowen, D D Patel

  • 1Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, WA 98121, USA. aruffo@bms.com

Immunology Today
|November 14, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The function and affinity maturation of HIV-1 gp120-specific monoclonal antibodies derived from colostral B cells.

Mucosal immunology·2015
Same author

Restricted isotype, distinct variable gene usage, and high rate of gp120 specificity of HIV-1 envelope-specific B cells in colostrum compared with those in blood of HIV-1-infected, lactating African women.

Mucosal immunology·2014
Same author

HIV-1 gp41 envelope IgA is frequently elicited after transmission but has an initial short response half-life.

Mucosal immunology·2013
Same author

Quantitating the multiplicity of infection with human immunodeficiency virus type 1 subtype C reveals a non-poisson distribution of transmitted variants.

Journal of virology·2009
Same author

Use of monoclonal antibodies for expression cloning.

Current protocols in immunology·2008
Same author

Transient expression of proteins using COS cells.

Current protocols in neuroscience·2008
Same journal

Foreword.

Immunology today·2020
Same journal

The origin and significance of anti-DNA antibodies.

Immunology today·2014
Same journal

Mutations of class II MHC molecules.

Immunology today·2014
Same journal

Antigen processing at the molecular level.

Immunology today·2014
Same journal

Phenotypically and functionally distinct T-cell subsets in anti-tumor responses.

Immunology today·2014
Same journal

Are MHC class II-restricted cytotoxic T lymphocytes important?

Immunology today·2014
See all related articles

The scavenger receptor cysteine-rich (SRCR) superfamily includes CD6, a lymphocyte receptor. This review details the CD6-ALCAM interaction, offering insights into SRCR domain ligand binding mechanisms.

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • The scavenger receptor cysteine-rich (SRCR) superfamily comprises proteins involved in cellular processes.
  • Leukocyte-expressed SRCR proteins are classified into groups A and B.
  • Group B includes CD6, a key lymphocyte cell-surface receptor.

Purpose of the Study:

  • To review recent advancements in understanding the CD6-ALCAM interaction.
  • To explore the significance of CD6-ALCAM binding in cellular communication.
  • To provide insights into broader SRCR domain-ligand binding mechanisms.

Main Methods:

  • Literature review of recent research on CD6 and ALCAM.
  • Analysis of molecular interactions between CD6 and ALCAM.
  • Comparative analysis of SRCR superfamily members and their ligands.

Related Experiment Videos

Main Results:

  • Recent progress highlights the intricate nature of the CD6-ALCAM interaction.
  • Understanding this interaction is crucial for deciphering leukocyte function.
  • The CD6-ALCAM system serves as a model for other SRCR-ligand interactions.

Conclusions:

  • The CD6-ALCAM interaction is a significant area of immunological research.
  • Further analysis of CD6-ALCAM binding will illuminate SRCR superfamily functions.
  • This review provides a foundation for future studies on SRCR-mediated cellular adhesion and signaling.