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C-terminal domain of transcription cofactor PC4 reveals dimeric ssDNA binding site
Nature Structural Biology
|November 14, 1997
Abstract:
The crystal structure of human replication and transcription cofactor PC4CTD reveals a dimer with two single-stranded (ss)DNA binding channels running in opposite directions to each other. This arrangement suggests a role in establishment or maintenance of melted DNA at promoters or origins of replication.