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Activity of liver proteases in experimental methanol intoxication
E Skrzydlewska1, Z Skrzydlewski, K Worowski
1Department of Instrumental Analysis, Medical Academy, Białystok, Poland.
Acta Biochimica Polonica
|January 1, 1997
Abstract:
Intoxication of rats with methanol (1.5 and 3.0 g/kg body weight) led to a significant, time- and dose-dependent decrease in the activities of cathepsins A, B and C, while the activity of cathepsin D was unaffected. The decrease was associated with a different partial release of individual cathepsins to the post-lysosomal fraction.