Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Logistics in acute stroke management

J P Broderick1

  • 1Department of Neurology, University of Cincinnati, Ohio, USA.

Drugs
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Timely administration of alteplase (recombinant tissue-type plasminogen activator; rt-PA) within 3 hours of stroke symptom onset significantly improves outcomes for acute ischemic stroke patients. Prompt recognition and emergency medical system access are crucial for effective treatment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Migraine-Associated Common Genetic Variants Confer Greater Risk of Posterior vs. Anterior Circulation Ischemic Stroke☆.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2022
Same author

Detailed phenotyping of posterior vs. anterior circulation ischemic stroke: a multi-center MRI study.

Journal of neurology·2019
Same author

<i>Reply</i>.

AJNR. American journal of neuroradiology·2017
Same author

Endovascular Therapy of M2 Occlusion in IMS III: Role of M2 Segment Definition and Location on Clinical and Revascularization Outcomes.

AJNR. American journal of neuroradiology·2016
Same author

Administration of S-methyl-L-thiocitrulline protects against brain injuries after intracerebral hemorrhage.

Neuroscience·2014
Same author

Matrix metalloproteinase-2 deletions protect against hemorrhagic transformation after 1 h of cerebral ischemia and 23 h of reperfusion.

Neuroscience·2013
Same journal

Botulinum Toxin Type A for Trigeminal and Postherpetic Neuralgia: An Umbrella Review of Systematic Reviews.

Drugs·2026
Same journal

Biologics and Small Molecule Inhibitors: Novel Therapeutic Strategies for Cutaneous Adverse Drug Reactions.

Drugs·2026
Same journal

Use of Sedative-Hypnotic Drugs and the Risk of Developing Alzheimer's Disease: A Systematic Review, Meta-Analysis and Meta-Regression.

Drugs·2026
Same journal

Relacorilant: First Approval.

Drugs·2026
Same journal

Developmental Progress and Future Potential for Inhaled Biologics in the Treatment of Respiratory Diseases.

Drugs·2026
Same journal

Linerixibat: First Approval.

Drugs·2026
See all related articles

Area of Science:

  • Neurology
  • Emergency Medicine
  • Pharmacology

Background:

  • Acute ischemic stroke treatment efficacy is time-sensitive.
  • Alteplase (recombinant tissue-type plasminogen activator; rt-PA) is a key thrombolytic agent.
  • Delays in stroke treatment initiation impact patient outcomes.

Purpose of the Study:

  • To review findings from National Institute of Neurological Disorders and Stroke (NINDS) studies on alteplase for acute ischemic stroke.
  • To identify factors delaying stroke treatment and propose solutions.
  • To highlight recommended time goals for stroke care.

Main Methods:

  • Analysis of NINDS study results on alteplase efficacy.
  • Identification of barriers to rapid stroke treatment.

Related Experiment Videos

  • Review of recommendations from the National Symposium on the Rapid Identification and Treatment of Acute Stroke.

    • Main Results:

    • Alteplase administration within 3 hours of symptom onset improves outcomes in selected acute ischemic stroke patients.
    • Failure to recognize stroke symptoms is a major delay factor.
    • Emergency medical systems should be accessed directly via emergency numbers.

    Conclusions:

    • Rapid identification and treatment of acute ischemic stroke are critical.
    • Hospitals should adhere to recommended time goals (e.g., 25 min to CT, 60 min to treatment).
    • Enhanced education, stroke triage as a level one emergency, and specialized training are necessary for optimal alteplase use and patient outcomes.