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Methotrexate use in rheumatoid arthritis
1Department of Internal Medicine, University of Nebraska Medical Center, Omaha, USA.
Rheumatic Diseases Clinics of North America
|November 15, 1997
Summary
Methotrexate is a highly effective and well-tolerated drug for rheumatoid arthritis management. This review covers its efficacy, toxicity, clinical use, combination therapy, and future applications in treating rheumatoid arthritis.
Area of Science:
- Rheumatology
- Clinical Pharmacology
Background:
- Methotrexate is a cornerstone therapy in rheumatoid arthritis.
- Its efficacy and tolerability have established its importance.
Purpose of the Study:
- To review the efficacy and toxicity data of methotrexate in rheumatoid arthritis.
- To discuss clinical use, combination therapy, and future directions.
Main Methods:
- Literature review of existing data on methotrexate.
- Analysis of clinical trial results and observational studies.
Main Results:
- Methotrexate demonstrates significant efficacy in managing rheumatoid arthritis.
- It is generally well-tolerated, though toxicity requires monitoring.
Conclusions:
- Methotrexate remains a vital treatment for rheumatoid arthritis.
- Understanding its profile is crucial for optimal patient outcomes.