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A novel transmembrane semaphorin can bind c-src

F Eckhardt1, O Behar, E Calautti

  • 1Cardiovascular Research Center, Massachusetts General Hospital (East), Charlestown 02129, USA.

Molecular and Cellular Neurosciences
|January 1, 1997
PubMed
Summary
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This study identifies Sema VIb, a novel mouse semaphorin involved in nervous system and muscle development. Sema VIb may function as a receptor, signaling through an src-related cascade.

Area of Science:

  • Molecular Biology
  • Neuroscience
  • Cell Biology

Background:

  • Semaphorins/collapsins are conserved gene families with a semaphorin domain.
  • They include secreted and transmembrane molecules, often acting as ligands.
  • Known functions include axonal pathfinding for some semaphorins.

Purpose of the Study:

  • To identify and characterize a novel mouse semaphorin, Sema VIb.
  • To investigate the potential role of Sema VIb in intracellular signaling pathways.

Main Methods:

  • Identification of mouse Sema VIb cDNA.
  • Analysis of Sema VIb mRNA expression during development and adulthood.
  • In vitro binding assays to study protein interactions.
  • Coimmunoprecipitation assays in transfected cells.

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Main Results:

  • Sema VIb mRNA is expressed in the nervous system and muscle during development, and ubiquitously in adults.
  • Sema VIb lacks immunoglobulin or thrombospondin repeats found in other vertebrate transmembrane semaphorins.
  • Sema VIb binds to the SH3 domain of c-src and coimmunoprecipitates with c-src.
  • Sema VIb can form dimers.

Conclusions:

  • Sema VIb is a transmembrane semaphorin with a unique domain structure.
  • Sema VIb interacts with c-src, suggesting a role in intracellular signaling.
  • The semaphorin family may include members that function as receptors, initiating signaling cascades.