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Carquinostatin B, a new neuronal cell-protecting substance produced by Streptomyces exfoliatus
K Shin-ya1, T Kunigami, J S Kim
1Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
Bioscience, Biotechnology, and Biochemistry
|November 15, 1997
Abstract:
Brain ischemia injury is elicited by the excitotoxicity of L-glutamate. Carquinostatin B was isolated from Streptomyces exfoliatus 2419-SVT2 as a potent neuroprotective substance which protests neuronal hybridoma N18-RE-105 cells from L-glutamate toxicity. The structure of carquinostatin B was established principally by NMR studies to be a carbazole derivative with an ortho quinone function.