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Related Experiment Videos

Functional property, norepinephrine content and morphometric findings in human hyperplastic prostate

M Ishigooka1, T Hashimoto, Y Suzuki

  • 1Department of Urology, Yamagata University School of Medicine, Japan. mishigo@med.id.yamagata-u.ac.jp

The Prostate
|November 20, 1997
PubMed
Summary

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The smooth muscle density in benign prostatic hyperplasia (BPH) tissue directly impacts its contractile response to alpha-adrenergic agonists. This finding clarifies how BPH tissue reacts to common BPH medications.

Area of Science:

  • Urology
  • Pharmacology
  • Histology

Background:

  • Alpha-adrenergic blockers are standard treatments for benign prostatic hyperplasia (BPH).
  • The relationship between smooth muscle density and prostate contractile function in BPH was previously unclear.

Purpose of the Study:

  • To investigate the correlation between smooth muscle density in BPH tissue and its contractile response to alpha-adrenergic agonists.
  • To evaluate the role of norepinephrine content in this response.

Main Methods:

  • Functional studies and quantitative morphometric analysis were conducted on human BPH specimens.
  • Tissue norepinephrine content was measured in conjunction with contractile responses to phenylephrine.

Main Results:

Related Experiment Videos

  • A significant linear correlation was found between smooth muscle density and maximum contractile response to phenylephrine (r = 0.457, P = 0.0362).
  • Smooth muscle density positively correlated with norepinephrine content (r = 0.437, P = 0.0471), but norepinephrine levels did not correlate with phenylephrine response.

Conclusions:

  • The contractile properties of BPH tissue in response to alpha-adrenergic agonists are directly influenced by the density of smooth muscle.
  • Smooth muscle density is a key determinant of the efficacy of alpha-adrenergic agonists in BPH treatment.