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Desflurane increases brain tissue oxygenation and pH

W E Hoffman1, F T Charbel, G Edelman

  • 1Department of Anaesthesiology, University of Illinois Hospital, Chicago, USA.

Acta Anaesthesiologica Scandinavica
|November 21, 1997
PubMed
Summary
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High concentrations of desflurane anesthesia improved brain tissue oxygenation and pH while lowering carbon dioxide levels. This suggests desflurane may benefit patients undergoing neurosurgery, especially those at risk of ischemia.

Area of Science:

  • Anesthesiology
  • Neurosurgery
  • Intracranial physiology

Background:

  • Desflurane anesthesia is known to affect cerebral metabolism and blood flow.
  • Understanding its impact on brain tissue gases and pH is crucial for neurosurgical procedures.

Purpose of the Study:

  • To evaluate the effect of varying concentrations of desflurane on brain tissue oxygen pressure (PO2), carbon dioxide pressure (PCO2), and pH during neurosurgery.

Main Methods:

  • A Paratrend 7 sensor was used to measure brain tissue PO2, PCO2, and pH after craniotomy.
  • Two groups were studied: a control group with constant 3% end-tidal desflurane and an experimental group where desflurane increased from 3% to 9%.

Main Results:

  • Increasing end-tidal desflurane to 9% led to burst-suppression EEG, significantly increased tissue PO2 and pH, and decreased PCO2.

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  • No significant changes in these parameters were observed in the control group.

    • Conclusions:

    • High-concentration desflurane (9%) can enhance brain tissue metabolic status before temporary arterial occlusion.
    • This effect is contingent on maintaining cerebral perfusion pressure and may be particularly beneficial for patients with pre-existing ischemia symptoms.