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Bone markers

P Garnero1, P D Delmas

  • 1INSERM Research Unit 403, Hôpital E. Herriot, Lyon, France.

Bailliere'S Clinical Rheumatology
|August 1, 1997
PubMed
Summary
This summary is machine-generated.

New biochemical markers enhance bone turnover assessment for osteoporosis. These markers improve fracture risk prediction in post-menopausal women and monitor treatment effectiveness.

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Area of Science:

  • Biochemistry
  • Metabolic Bone Diseases
  • Osteoporosis Research

Background:

  • Non-invasive assessment of bone turnover is crucial for metabolic bone diseases like osteoporosis.
  • Specific and sensitive biochemical markers have significantly advanced this assessment.

Purpose of the Study:

  • To highlight the utility of novel biochemical markers for bone formation and resorption.
  • To discuss their role in predicting osteoporosis and monitoring treatment efficacy.

Main Methods:

  • Immunoassays for human osteocalcin and bone alkaline phosphatase assess bone formation.
  • High-pressure liquid chromatography for urinary pyridinoline crosslinks measures bone resorption.
  • Development of immunoassays for pyridinoline crosslinks and collagen peptides.

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Main Results:

  • Human osteocalcin and bone alkaline phosphatase are sensitive bone formation markers.
  • Urinary pyridinoline crosslinks are superior markers for osteoporosis assessment.
  • Newer immunoassays promise broader clinical application for resorption markers.

Conclusions:

  • Biochemical markers improve prognostic assessment of osteoporosis and fracture risk in post-menopausal women.
  • These markers are valuable for monitoring the efficacy of anti-resorption therapies.
  • Further studies are defining the clinical applications of these advanced bone turnover markers.