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Related Experiment Videos

Wingless signaling generates pattern through two distinct mechanisms

R Hays1, G B Gibori, A Bejsovec

  • 1Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208-3500, USA.

Development (Cambridge, England)
|November 21, 1997
PubMed
Summary
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Wingless (Wg) signaling in Drosophila patterns embryonic development by specifying distinct cell fates. This study reveals separate pathways for denticle diversity and naked cuticle, suggesting multiple Wg receptors and intercellular transport are key.

Area of Science:

  • Developmental Biology
  • Molecular Genetics
  • Cell Signaling

Background:

  • Wingless (Wg) and Wnt genes are crucial for embryonic pattern formation.
  • Wg signaling in Drosophila influences epidermal cell identities across multiple rows.
  • Wg specifies distinct patterns: denticle diversity and naked cuticle.

Purpose of the Study:

  • To investigate how a single secreted molecule, Wg, specifies distinct cell fates.
  • To explore the mechanisms underlying Wg's role in epidermal pattern formation.
  • To elucidate the pathways and receptors involved in Wg signaling.

Main Methods:

  • Manipulation of wild-type and mutant wingless (wg) transgenes in Drosophila.
  • Analysis of Wg protein distribution and its effect on cell fate specification.

Related Experiment Videos

  • Investigation of conserved and non-conserved regions of the Wingless protein.

    • Main Results:

    • Evidence suggests distinct cellular pathways for naked cuticle and denticle diversity.
    • Differential activation by mutant Wg ligands implies at least two Wg receptor classes.
    • Broad Wg protein distribution is essential for denticle diversity, indicating intercellular transport.
    • An 85 amino acid region absent in vertebrate Wnts is dispensable for Wg function.

    Conclusions:

    • Wg signaling utilizes distinct pathways and potentially multiple receptors to specify different cell fates.
    • Intercellular transport of Wg protein is vital for epidermal pattern formation.
    • Structural features of Wg are required for its diverse biological activities.