Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chromosomal analysis to assess radiation dose

D C Lloyd1

  • 1National Radiological Protection Board, Didcot, Oxon, UK.

Stem Cells (Dayton, Ohio)
|January 1, 1997
PubMed
Summary

Cytogenetic assays offer a sensitive and rapid method for estimating radiation dose. These chromosome studies aid physicians in medical management, including triage and counseling for exposed individuals.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Eurados review of retrospective dosimetry techniques for internal exposures to ionising radiation and their applications.

Radiation and environmental biophysics·2020
Same author

In situ oxidation and reduction of triangular nickel nanoplates via environmental transmission electron microscopy.

Journal of microscopy·2017
Same author

An update of the WHO Biodosenet: Developments since its Inception.

Radiation protection dosimetry·2016
Same author

A follow-up cytogenetic study of workers highly exposed inside the Chernobyl sarcophagus.

Radiation protection dosimetry·2014
Same author

Biological dosimetry assessments of a serious radiation accident in Bulgaria in 2011.

Radiation protection dosimetry·2013
Same author

The capacity, capabilities and needs of the WHO BioDoseNet member laboratories.

Radiation protection dosimetry·2012

Area of Science:

  • Radiation biology
  • Medical physics
  • Cytogenetics

Background:

  • Cytogenetic assays are crucial for biological dosimetry.
  • Assessing radiation exposure requires sensitive and rapid methods.
  • Physician guidance is essential for managing irradiated patients.

Purpose of the Study:

  • To review the sensitivity and speed of cytogenetic assays for radiation dosimetry.
  • To discuss the clinical utility of chromosome studies in medical management.
  • To highlight the role of cytogenetics in patient counseling.

Main Methods:

  • Review of existing literature on cytogenetic dosimetry.
  • Analysis of chromosome aberrations for dose estimation.
  • Evaluation of the speed and sensitivity of cytogenetic techniques.

Main Results:

  • Cytogenetic assays provide sensitive and rapid dose estimates.
  • Chromosome studies help confirm triage categories for high-dose exposures.
  • These assays can indicate non-uniform exposure and surviving stem cells.

Conclusions:

  • Cytogenetic dosimetry is valuable for medical management decisions, including stem cell transplantation and growth factor therapy.
  • Useful for counseling patients exposed to low or zero doses.
  • Supports clinical decisions by providing objective biological data.

Related Experiment Videos