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[Current problems in quality control (QC) in hematology]

N Tatsumi1, T Takubo, I Tsuda

  • 1Department of Clinical and Laboratory Medicine, Osaka City University Medical School.

Rinsho Byori. the Japanese Journal of Clinical Pathology
|November 22, 1997
PubMed
Summary
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Developing quality control (QC) materials for laboratory hematology is crucial. Current methods for mean cell volume (MCV) and white cell differential analysis lack standardization, necessitating new QC solutions for accurate blood cell counting.

Area of Science:

  • Laboratory Hematology
  • Clinical Diagnostics

Context:

  • Total quality control (TQC) is vital in laboratory hematology.
  • Automated blood cell counters offer robust quality control (QC) for complete blood count (CBC) and reticulocyte determinations.
  • Current QC materials exhibit variability for mean cell volume (MCV) and lack standardization for white cell differential analysis.

Purpose:

  • To highlight the need for standardized quality control (QC) materials in hematology.
  • To address the limitations in current QC for specific hematologic parameters like MCV and white cell differentials.
  • To emphasize the requirement for developing universal QC materials for all blood cell counters.

Summary:

  • While automated counters provide reliable CBC and reticulocyte counts, inconsistencies exist in MCV measurements using available QC materials.

Related Experiment Videos

  • There is a significant lack of QC materials for evaluating white cell differential functions across different laboratory instruments.
  • Variability in prothrombin time (PT) and activated partial thromboplastin time (APTT) reagents, impacting international normalized ratio (INR) standardization, also requires attention.

    • Impact:

    • Development of new QC materials will enhance the accuracy and comparability of hematologic test results across different laboratories and instruments.
    • Improved QC will lead to more reliable patient diagnoses and treatment monitoring.
    • Standardization in coagulation testing (PT/APTT) will improve the consistency of international normalized ratio (INR) reporting.