Choleretic effect of vasoactive intestinal peptide

Area of Science:

• Gastroenterology
• Endocrinology
• Physiology

Background:

• Vasoactive intestinal peptide (VIP) is a peptide hormone with diverse physiological roles.
• VIP is known to influence gastrointestinal and biliary functions.
• Understanding VIP's effect on bile secretion is crucial for gastrointestinal research.

Purpose of the Study:

• To investigate the effects of intravenous vasoactive intestinal peptide (VIP) on bile output and composition in anesthetized dogs.
• To determine if feeding status influences VIP's impact on biliary secretion.

Main Methods:

• Anesthetized dogs with common bile duct fistulas were infused intravenously with VIP at dosages of 0.05 and 0.5 mug/kg/min.
• Bile output, sodium, and amylase concentrations were measured in fasting and fed states.
• Control measurements were taken before VIP administration.

Main Results:

• VIP administration significantly increased bile output by approximately 200% in fasting dogs.
• Biliary sodium concentration remained constant, while amylase concentration decreased.
• In fed dogs, VIP had no significant effect on bile output.
• Higher VIP dosage (0.5 mug/kg/min) resulted in a doubled or trebled duration of effect compared to the lower dose.

Conclusions:

• Vasoactive intestinal peptide (VIP) stimulates bile secretion in fasting animals.
• The effect of VIP on bile output is dependent on the animal's feeding status.
• VIP may play a role in regulating bile flow, particularly under fasting conditions.