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Olfactory dysfunction in familial parkinsonism

K Markopoulou1, K W Larsen, E K Wszolek

  • 1Section of Neurology, University of Nebraska Medical Center, Omaha, NE, USA.

Neurology
|December 31, 1997
PubMed
Summary
This summary is machine-generated.

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Olfactory dysfunction, or impaired smell, is a common trait in familial parkinsonism, affecting most affected individuals. This smell impairment appears early and is independent of specific parkinsonian phenotypes.

Area of Science:

  • Neurology
  • Genetics
  • Neuroscience

Background:

  • Idiopathic Parkinson's disease (IPD) is frequently associated with impaired olfactory function.
  • The presence of olfactory dysfunction in familial parkinsonism has not been previously established.

Purpose of the Study:

  • To investigate olfactory function in individuals with familial parkinsonism.
  • To determine if olfactory dysfunction is a characteristic phenotype of familial parkinsonism.

Main Methods:

  • Smell tests were administered to affected, monosymptomatic, and at-risk individuals from six parkinsonian kindreds.
  • Participants were categorized based on phenotype: IPD or parkinsonism-plus syndrome (PPS).

Main Results:

  • All but one affected individual exhibited impaired olfactory function.

Related Experiment Videos

  • Five of 12 at-risk individuals showed olfactory impairment, with less severity than affected individuals.
  • No statistically significant difference in olfactory impairment was found between IPD and PPS phenotypes.

    • Conclusions:

    • Olfactory dysfunction is a phenotypic characteristic of familial parkinsonism.
    • This olfactory impairment is independent of the specific parkinsonian kindred phenotype.
    • Early onset of olfactory dysfunction suggests a role in the neurodegenerative process.