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Related Experiment Videos

Risk factors for developing multiple sclerosis after childhood optic neuritis

C F Lucchinetti1, L Kiers, A O'Duffy

  • 1Department of Neurology, Mayo Clinic, Rochester, MN, USA.

Neurology
|December 31, 1997
PubMed
Summary

Childhood optic neuritis (ON) has a lower risk of progressing to multiple sclerosis (MS) in children compared to adults. Bilateral or recurrent ON increases MS risk, while preceding infection may decrease it.

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Area of Science:

  • Pediatric Neurology
  • Ophthalmology
  • Neuroimmunology

Background:

  • Optic neuritis (ON) is an inflammatory condition affecting the optic nerve.
  • Understanding the long-term outcomes of childhood ON is crucial for prognosis and management.
  • Previous studies have primarily focused on adult populations.

Purpose of the Study:

  • To investigate the long-term risk of developing multiple sclerosis (MS) after childhood optic neuritis (ON).
  • To identify factors influencing the progression from ON to MS in pediatric patients.

Main Methods:

  • Retrospective review of 94 pediatric ON cases (age < 16) diagnosed at Mayo Clinic (1950-1988).
  • Detailed follow-up data available for 79 patients (median 19.4 years).
  • Life-table analysis used to determine cumulative incidence of MS development.

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Main Results:

  • 13% of patients developed definite MS by 10 years, 26% by 40 years.
  • Factors like gender, age, visual acuity, or family history did not predict MS development.
  • Bilateral/recurrent ON significantly increased MS risk (HR=5.09), while preceding infection decreased risk (HR=0.24).

Conclusions:

  • Childhood ON carries a lower risk of progression to MS compared to adults.
  • Recurrent or bilateral ON presentation is a significant risk factor for MS development in children.
  • Infection preceding ON onset may have a protective effect against MS development.