Related Experiment Video
Updated: Aug 11, 2026

Measuring Volatile and Non-volatile Antifungal Activity of Biocontrol Products
Published on: December 5, 2020
Anti-inflammatory activity of antifungal preparations
T Rosen1, B J Schell, I Orengo
1Department of Dermatology, Baylor College of Medicine, Houston, Texas, USA.
Background:
Although steroid/antifungal combination medications are used extensively, they are associated with potential disadvantages. Antifungal preparations possessing inherent anti-inflammatory activity, leading to rapid symptomatic relief while providing mycologic cure, would be very useful.
Objective:
Our purpose was to investigate the anti-inflammatory activity of proprietary antifungal preparations in an in vivo, human experimental model.
Methods:
Using a double-blind, controlled protocol, we assessed the comparative ability of antifungal preparations to suppress the expected delayed erythema response following in vivo human exposure to ultraviolet B (UVB) irradiation generated by a solar stimulator.
Results:
Currently available allylamine preparations and ciclopirox olamine proved to be the most anti-inflammatory, while ketoconazole was intermediate in anti-inflammatory activity under these experimental conditions. These agents were superior to oxiconazole, econazole, and 2.5% hydrocortisone.
Conclusions:
Some antifungal preparations possess inherent anti-inflammatory activity, although the exact mechanism remains uncertain.
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