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Fletcher factor deficiency and myocardial infarction
American Journal of Clinical Pathology
|June 1, 1976
Summary
Severe Fletcher factor deficiency, a rare clotting disorder, was observed in a patient experiencing acute myocardial infarction. This case highlights alternative pathways in blood systems crucial for infarction development.
Area of Science:
- Hematology
- Cardiology
- Biochemistry
Background:
- Fletcher factor deficiency is a rare inherited coagulation disorder.
- It is associated with defects in clotting, fibrinolysis, and kinin generation systems.
- These systems are implicated in the pathogenesis of myocardial infarction.
Purpose of the Study:
- To describe a case of acute myocardial infarction in a patient with severe Fletcher factor deficiency.
- To emphasize the role of alternate activation pathways in systems affected by Fletcher factor deficiency.
Main Methods:
- Case report description.
- Analysis of patient's coagulation parameters.
- Review of literature on Fletcher factor deficiency and myocardial infarction.
Main Results:
- A patient with acute myocardial infarction presented with Fletcher factor concentration <1% of normal.
- The patient's condition underscores the interplay between clotting, fibrinolysis, and kinin generation in infarction.
Conclusions:
- The development of myocardial infarction in severe Fletcher factor deficiency highlights the significance of alternative activation pathways.
- Understanding these pathways is crucial for managing patients with combined hemostatic and cardiovascular conditions.