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Isolation and characterization of cytotoxic diterpenoid isomers from propolis
T Matsuno1, Y Matsumoto, M Saito
1National Institute of Health, Tokyo, Japan.
Zeitschrift Fur Naturforschung. C, Journal of Biosciences
|November 28, 1997
Abstract:
The methanol extract of Brazilian propolis was fractionated by HPLC, based on HuH13 (human hepatocellular carcinoma) cell cytotoxicity assay. Two isomers of diterpenoid with a molecular formula of C20H30O3 (MW: 318.46) were isolated. The structures of these colorless compounds were determined as clerodane diterpenoids (I, 15-oxo-3, 13Z-kolavadien-17-oic acid; II, 15-oxo-3Z, 13E-kolavadien-17-oic acid).