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Related Experiment Videos

Serotonin function and antiaggressive response to fluoxetine: a pilot study

E F Coccaro1, R J Kavoussi, R L Hauger

  • 1Department of Psychiatry, MCP, Hahnemann School of Medicine, Philadelphia, PA 19129, USA.

Biological Psychiatry
|October 6, 1997
PubMed
Summary
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This study found that a higher prolactin response to d-fenfluramine (PRL[d-FEN]) predicted reduced aggression in impulsive individuals treated with fluoxetine. This suggests serotonin

Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • A link exists between lower central serotonin (5-HT) function and increased impulsive aggression.
  • Enhancing 5-HT activity may reduce aggressive behavior, but baseline 5-HT function's role in treatment response is unclear.

Purpose of the Study:

  • To investigate the relationship between baseline central 5-HT function and antiaggressive treatment response in personality disordered subjects.
  • To examine if pretreatment prolactin response to d-fenfluramine (PRL[d-FEN]) predicts antiaggressive outcomes.

Main Methods:

  • Pilot study involving 15 impulsively aggressive personality disordered subjects.
  • 12-week double-blind, placebo-controlled trial comparing fluoxetine and placebo.
  • Assessed pretreatment PRL[d-FEN] challenge and antiaggressive responses using Overt Aggression Scale-Modified.

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Main Results:

  • Positive correlations observed between pretreatment PRL[d-FEN] response and improvement in aggression and irritability scores.
  • These correlations were significant in the fluoxetine group (n=10) but not in the placebo group (n=5).

Conclusions:

  • The antiaggressive effect of fluoxetine may depend directly on central 5-HT synapse responsiveness.
  • Baseline 5-HT function, indicated by PRL[d-FEN] response, could predict treatment efficacy in impulsive aggression.