Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Homeobox genes in embryogenesis and pathogenesis

M Mark1, F M Rijli, P Chambon

  • 1Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP/Collège de France, Illkirch, France.

Pediatric Research
|October 6, 1997
PubMed
Summary

Homeobox genes, crucial for development, regulate gene expression and morphogenesis. Recent studies explore their roles in mammalian development, congenital malformations, and cancer.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sex-specific efficacy and safety outcomes in patients with resectable stage III non-small-cell lung cancer (NSCLC) undergoing neoadjuvant therapies: a pooled analysis of the SAKK trials 16/96, 16/00, 16/01, 16/08 and 16/14.

ESMO open·2025
Same author

First Constraints on General Neutrino Interactions Based on KATRIN Data.

Physical review letters·2025
Same author

Neoadjuvant treatment does not influence PD-L1 expression in stage III non-small-cell lung cancer: a retrospective analysis of tumor samples from the trials SAKK 16/96, 16/00, 16/01, and 16/14.

ESMO open·2023
Same author

New Constraint on the Local Relic Neutrino Background Overdensity with the First KATRIN Data Runs.

Physical review letters·2022
Same author

Corrigendum to 'Long-term outcomes of operable stage III NSCLC in the pre-immunotherapy era: results from a pooled analysis of the SAKK 16/96, SAKK 16/00, SAKK 16/01, and SAKK 16/08 trials': [ESMO Open Volume 7, Issue 2, (2022), 100455].

ESMO open·2022
Same author

Long-term benefit of lurbinectedin as palliative chemotherapy in progressive malignant pleural mesothelioma (MPM): final efficacy and translational data of the SAKK 17/16 study.

ESMO open·2022

Area of Science:

  • Developmental Biology
  • Genetics
  • Molecular Biology

Background:

  • Homeobox genes encode DNA-binding proteins regulating gene expression.
  • The Hox family is vital for vertebrate embryonic morphogenesis and body axis patterning.
  • Divergent homeobox genes, though non-clustered, form families based on homology and function.

Purpose of the Study:

  • To review recent studies on homeobox gene functions in mammalian development.
  • To examine the involvement of homeobox genes in congenital malformations.
  • To explore the role of homeobox genes in oncogenesis.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of functional studies in mammalian models.
  • Examination of genetic data related to malformations and cancer.

Main Results:

  • Homeobox genes are fundamental regulators of cell differentiation and morphogenesis.
  • Aberrant homeobox gene function is linked to congenital abnormalities.
  • Dysregulation of homeobox genes contributes to oncogenesis.

Conclusions:

  • Homeobox genes are essential for normal mammalian development.
  • Understanding homeobox gene function is critical for diagnosing and treating developmental disorders and cancer.

Related Experiment Videos