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Role and regulation of phospholipase D activity in normal and cancer cells
M J Wakelam1, A Martin, M N Hodgkin
1Institute for Cancer Studies, University of Birmingham, U.K.
Advances in Enzyme Regulation
|January 1, 1997
Abstract:
PLD is regulated by the small GTP binding proteins Rho and Arf, though predominantly by the latter. The PA product of PLD activation is an activator of Rho-regulated actin stress fibre formation and in invasive cells of MMP-9 synthesis and activation. Together this may explain the increased invasion of cells in response to PA.