Related Experiment Videos
Recombination initiation: easy as A, B, C, D... chi?
1Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Potters Bar, Hertfordshire EN6 3LD, UK.
Current Biology : CB
|February 21, 1998
Abstract:
The octameric Chi (chi) sequence is a recombination hotspot in Escherichia coli. Recent studies suggest a singular mechanism by which chi regulates not only the nuclease activity of RecBCD enzyme, but also the ability of RecBCD to promote loading of the strand exchange protein, RecA, onto chi-containing DNA.