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Rhinal cortex lesions impair simultaneous olfactory discrimination learning in rats

T Otto1, D Garruto

  • 1Department of Psychology, Rutgers University, New Brunswick, New Jersey 08903, USA.

Behavioral Neuroscience
|February 12, 1998
PubMed
Summary
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Lesions in the perirhinal and entorhinal (PRER) cortical areas impaired rats' ability to learn simultaneous olfactory discriminations. This contrasts with previous findings on successive discriminations, suggesting PRER’s role in complex odor learning.

Area of Science:

  • Neuroscience
  • Olfactory learning
  • Memory research

Background:

  • Previous research indicated combined perirhinal and entorhinal (PRER) cortical lesions do not impair, and may enhance, successive olfactory discrimination acquisition.
  • The role of PRER in simultaneous olfactory discrimination remains less understood.

Purpose of the Study:

  • To investigate the impact of PRER lesions on the acquisition of simultaneous olfactory discriminations in rats.
  • To clarify the contribution of PRER cortex to different types of olfactory learning.

Main Methods:

  • Utilized 24 male rats, with 9 receiving PRER lesions and 15 serving as sham-operated controls.
  • Trained all subjects on a single simultaneous olfactory discrimination task.
  • Assessed acquisition performance between the lesioned and control groups.

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Main Results:

  • PRER-lesioned rats exhibited significant and persistent impairment in acquiring the simultaneous olfactory discrimination.
  • Performance deficits in lesioned animals were notable compared to sham-operated controls.

Conclusions:

  • The perirhinal and entorhinal cortices are crucial for acquiring simultaneous, but not successive, olfactory discriminations.
  • These findings support the role of PRER, alongside the hippocampus, in encoding relationships between multiple sensory stimuli.