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Input-increase and input-decrease types of cortical reorganization after upper extremity amputation in humans

T Elbert¹, A Sterr, H Flor

¹University of Konstanz, Germany. thomas.elbert@uni-konstanz.de

Experimental Brain Research

|January 10, 1998

Summary

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Following upper extremity amputation, the brain

Area of Science:

Neuroscience
Neuroplasticity
Somatosensory Cortex

Background:

Cortical remodeling occurs with changes in sensory input.
Previous studies observed reorganization in response to input loss or gain separately.

Purpose of the Study:

To investigate concurrent cortical reorganization after a single intervention.
To examine brain plasticity following upper extremity amputation.

Main Methods:

Magnetic Source Imaging (MSI) was used.
Tactile stimulation of the lip was applied in adult humans post-amputation.

Main Results:

Lip stimulation activated the face area and the hand's cortical region.
The cortical amputation zone showed "invasion" by adjacent sensory maps.

Related Experiment Videos

Representation of the intact hand's digits significantly increased in size.

Conclusions:

Upper extremity amputation induces concurrent cortical reorganization.
Sensory input can invade deafferented cortical areas.
Increased reliance on the remaining limb drives expansion of its cortical representation.