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Updated: Jul 30, 2026
07:04
Creation of Two Saccular Elastase-Digested Aneurysms with Different Hemodynamics in One Rabbit
Published on: April 15, 2021
[Histological findings in aneurysm treated with IDC: scanning electron microscopical study]
T Koizumi1, T Kawano, K Kazekawa
1Department of Neurosurgery, Fukuoka Tokushukai General Hospital.
No Shinkei Geka. Neurological Surgery
|December 5, 1997
Summary
Scanning electron microscopy revealed endothelial cell development on coils used to treat a brain aneurysm. This case is the first to document endothelial proliferation over coils in a human, highlighting the need for more histopathological data.
Area of Science:
- Neurology
- Pathology
- Vascular Surgery
Background:
- Aneurysms are a significant cause of morbidity and mortality.
- Endovascular coiling is a common treatment for aneurysms.
- Histopathological data on coil embolization in humans is limited.
Observation:
- A 78-year-old male presented with hemiparesis and dysphagia.
- A right internal carotid artery aneurysm was treated with interlocking detachable coils (IDC).
- Scanning electron microscopy of the resected aneurysm revealed endothelial cells on the coil surface.
Findings:
- Complete embolization of the aneurysm was achieved post-procedure.
- The patient unfortunately died of aspiration pneumonia.
- Histopathological analysis showed significant endothelialization of the IDC material.
Implications:
- This is the first reported case of endothelial proliferation over IDC in a human aneurysm.
- Findings suggest potential for improved aneurysm healing and stability with IDC.
- Further histopathological studies and long-term follow-up are crucial to validate these observations.
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