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Effects of lovastatin on the immune system
M F Muldoon1, J D Flory, A Marsland
1Center for Clinical Pharmacology, University of Pittsburgh Cancer Institute, Pennsylvania 15260, USA.
The American Journal of Cardiology
|December 5, 1997
Abstract:
Laboratory investigations have demonstrated that blockade of HMG-CoA reductase in vitro reduces lymphocyte proliferation in response to mitogens as well as other facets of the immune system, such as natural killer cell cytotoxicity. However, in this randomized and double-blind clinical investigation, treatment with 20-mg lovastatin for 6 months did not significantly alter several enumerative and functional characteristics of circulating immune cells.