[Expression of retroviral transmembrane envelope protein p15E in human malignant cells]

Malignant tumor growth is always accompanied with immune suppression. Tumor-derived immuno-suppressive factors, among others, are thought to be responsible, but their nature is not well defined. The paper reports on the expression of an immuno-suppressive retroviral transmembrane envelope protein p15E at different levels in human cancer cells. By using immunohistochemistry, enzyme-linked immunosorbent assay, flow cytometry and in situ hybridization, p15E expression could be demonstrated in cancers of the esophagus, nosopharynx, rectum, ovary (including malignant effusion and cell lines), stomach and breast. Enhanced expression of p15E was also observed in activated lymphocytes of cancer patients as shown by RT-PCR technique. The results indicate that p15E of tumor origin, and perhaps that from activated lymphocytes, may contribute to the immune suppression associated with malignancy.