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Paradigms for Pharmacological Characterization of C. elegans Synaptic Transmission Mutants
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Enhanced choline acetyltransferase activity does not explain the action of inhaled convulsants

R Griffiths1, P Ionescu, Z Fang

  • 1University Department of Anaesthesia, Leicester Royal Infirmary.

British Journal of Anaesthesia
|December 9, 1997
PubMed

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Indirect-acting cholinergic agonists are agents that interact with the acetylcholinesterase enzyme in the synaptic cleft, preventing the breakdown of acetylcholine into choline and acetate. Consequently, the concentration of acetylcholine in the synaptic cleft increases. These agonists can be classified into reversible and irreversible inhibitors based on their duration of action.
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