Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Local INR correction: justification for a simplified approach

S Craig1, K J Stevenson, J M Dufty

  • 1Throbosis Reference Centre, Withington Hospital, Manchester, UK.

Journal of Clinical Pathology
|December 9, 1997
PubMed
Summary

Correcting International Normalized Ratio (INR) reporting errors is possible using System International Sensitivity Index (System ISI) methods. The simplest approach involves plotting log reference INR against log local prothrombin time.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of a Binational Clinical Registry for Emergency Care: Data Completeness Across 11 Australian and Aotearoa New Zealand ED Networks.

Emergency medicine Australasia : EMA·2026
Same author

Timing matters: expanding the role of intravenous dexamethasone in caesarean delivery. A letter to the Editor.

International journal of obstetric anesthesia·2025
Same author

Gamma-ray dose threshold for MAPbI<sub>3</sub> solar cells.

Physical chemistry chemical physics : PCCP·2024
Same author

Revisiting the Profile of Patients with No Fixed Abode Admitted to Psychiatric Inpatient Units, 2017-2021.

Irish medical journal·2023
Same author

Complex diffusion-based kinetics of photoluminescence in semiconductor nanoplatelets.

Physical chemistry chemical physics : PCCP·2020
Same author

New biomarkers improve stratification of patients with melanoma.

The British journal of dermatology·2020

Area of Science:

  • Clinical Pathology
  • Laboratory Medicine
  • Medical Diagnostics

Background:

  • International Normalized Ratio (INR) reporting errors can impact patient care.
  • The System International Sensitivity Index (System ISI) offers a potential solution for INR correction.
  • Standardization of INR measurements across different laboratories is crucial.

Purpose of the Study:

  • To evaluate the effectiveness of various procedures for correcting INR reporting errors.
  • To assess the validity of using System ISI for INR calibration.
  • To identify the most reliable and simplest method for INR correction.

Main Methods:

  • Prothrombin times were measured for multiple calibrants and plasmas across 57 international centers.
  • Different regression analyses (linear and orthogonal) were applied to test various data relationships.

Related Experiment Videos

  • Calibrations were performed using international reference preparations and a four-center exercise.

    • Main Results:

    • Uncorrected INR data showed a mean deviation of 19.0% and high variability (CV 11.30-17.29%).
    • All tested methods successfully reduced INR variability (CV < 7%).
    • Specific regression methods, particularly log-log plots, demonstrated the best fit and accuracy for INR correction.

    Conclusions:

    • INR correction is achievable using multiple methods, including System ISI assignment.
    • The simplest and effective method involves linear regression of log reference INR against log local prothrombin time.
    • Accurate INR reporting is essential for effective anticoagulant therapy management.