Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Naltrexone in young autistic children: replication study and learning measures

B K Kolmen1, H M Feldman, B L Handen

  • 1Children's Hospital of Pittsburgh, PA, USA.

Journal of the American Academy of Child and Adolescent Psychiatry
|December 12, 1997
PubMed
Summary

Naltrexone showed modest behavioral improvements in some young autistic children, but did not impact learning. This study evaluated naltrexone

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Extraction of Teeth with the Proper Use of Elevators to Conserve the Investing Tissues.

The Dental register·2021
Same author

Integrating Biomarker Outcomes into Clinical Trials for Alzheimer's Disease in Down Syndrome.

The journal of prevention of Alzheimer's disease·2020
Same author

Relationship of amyloid beta and neurofibrillary tau deposition in Neurodegeneration in Aging Down Syndrome (NiAD) study at baseline.

Alzheimer's & dementia (New York, N. Y.)·2020
Same author

A Comparison of Quantitative R1 and Cortical Thickness in Identifying Age, Lifespan Dynamics, and Disease States of the Human Cortex.

Cerebral cortex (New York, N.Y. : 1991)·2020
Same author

Use of the single subject design for practice based primary care research.

Postgraduate medical journal·2005
Same author

Anticoagulation and incidence of late cerebrovascular accidents following the Fontan procedure.

Pediatric cardiology·2004

Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Pharmacology

Background:

  • Autism Spectrum Disorder (ASD) affects behavior and learning in young children.
  • Previous research explored naltrexone's potential benefits for autistic children.
  • Further investigation into naltrexone's efficacy and safety in this population is warranted.

Purpose of the Study:

  • To assess the efficacy and safety of naltrexone in young children with autistic disorder.
  • To evaluate naltrexone's impact on behavioral and learning measures.
  • To expand upon existing research regarding naltrexone for autism.

Main Methods:

  • A randomized, double-blind, crossover study involving 24 children with autistic disorder (aged 3.0-8.3 years).
  • Naltrexone (1.0 mg/kg/day) was administered in home, school, and laboratory settings.

Related Experiment Videos

  • Evaluated outcomes included parent/teacher ratings (CGI, SE), behavioral factors, and learning assessments (EIDP-Language, paired-associate learning).

    • Main Results:

    • Naltrexone showed statistically significant improvements compared to baseline on parent and teacher ratings.
    • Eleven of 24 children demonstrated improvement in two or more settings.
    • No significant changes were observed in learning measure scores across conditions.

    Conclusions:

    • Naltrexone was associated with modest behavioral improvements in a subset of young autistic children.
    • The medication did not demonstrate a positive effect on learning outcomes.
    • Mild side effects were noted, and administration presented challenges.