Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Alu sequences

A J Mighell1, A F Markham, P A Robinson

  • 1Molecular Medicine Unit, The University of Leeds, St. James's University Hospital, UK. A.J.Mighell@leeds.ac.uk

FEBS Letters
|December 12, 1997
PubMed
Summary
This summary is machine-generated.

Alu sequences are common in human DNA. This review covers their origin, evolution, and diverse roles in gene expression, including effects on RNA polymerase II and III.

Related Experiment Videos

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Novel Ameloblastin Variants, Contrasting Amelogenesis Imperfecta Phenotypes.

Journal of dental research·2023
Same author

The burden of dental care in Amelogenesis Imperfecta paediatric patients in the UK NHS: a retrospective, multi-centred analysis.

European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry·2021
Same author

Development of orthotopic tumour models using ultrasound-guided intrahepatic injection.

Scientific reports·2019
Same author

Phenotype and Variant Spectrum in the LAMB3 Form of Amelogenesis Imperfecta.

Journal of dental research·2019
Same author

Genetic testing for amelogenesis imperfecta: knowledge and attitudes of paediatric dentists.

British dental journal·2018
Same author

Oral Medicine for undergraduate dental students in the United Kingdom and Ireland-A curriculum.

European journal of dental education : official journal of the Association for Dental Education in Europe·2018
Same journal

Identification of a Shiga toxin A-derived peptide internalized into Gb3 receptor-bearing cells via interaction with the Shiga toxin B subunit.

FEBS letters·2026
Same journal

The dual role of lectins in cancer-immunotherapy tools and therapeutic targets.

FEBS letters·2026
Same journal

Decoding the dynamic extracellular matrix in cancer-3D models and bioscaffolds rewire the rules of tumor progression.

FEBS letters·2026
Same journal

Extending the classical sequence-structure-function paradigm through protein dynamics and context-dependent behavior.

FEBS letters·2026
Same journal

α-Synuclein aggregation landscape from phase separation to neurotoxic intermediates.

FEBS letters·2026
Same journal

Modelling stem cell differentiation related processes-A practical overview for biologists.

FEBS letters·2026
See all related articles

Area of Science:

  • Genomics
  • Molecular Biology
  • Evolutionary Biology

Background:

  • Alu sequences are a major component of human repetitive DNA.
  • They are frequently observed in human genomic nucleic acid studies.

Purpose of the Study:

  • To review the origin, amplification, and evolution of Alu sequences.
  • To discuss the functional roles of Alu sequences in gene expression.

Main Methods:

  • Literature review of Alu sequence research.
  • Analysis of Alu sequence impact on gene expression mechanisms.

Main Results:

  • Alu sequences have distinct evolutionary subfamilies.
  • They influence RNA polymerase II-mediated gene expression.
  • Alu sequences are present in RNA polymerase III transcripts.

    • Conclusions:

    • Alu sequences play multifaceted roles in the human genome.
    • Understanding Alu sequences is crucial for comprehending gene regulation.