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Related Experiment Videos

Electroacupuncture reduces morphine-induced emesis in ferrets: a pilot study

L Lao1, R H Wong, B Berman

  • 1Department of Family Medicine, School of Medicine, University of Maryland at Baltimore, USA.

Journal of Alternative and Complementary Medicine (New York, N.Y.)
|October 1, 1995
PubMed
Summary

Electroacupuncture (EA) effectively reduced morphine-induced vomiting in ferrets. This study shows EA

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Area of Science:

  • Neuroscience
  • Integrative and Complementary Medicine

Background:

  • Morphine is a potent analgesic but frequently causes nausea and vomiting.
  • Acupuncture, particularly electroacupuncture (EA), is explored for its antiemetic potential.

Purpose of the Study:

  • To investigate the efficacy of electroacupuncture (EA) at the Neiguan (P6) acupoint as an antiemetic therapy against morphine-induced emesis in a ferret model.

Main Methods:

  • Ferrets were administered morphine to induce emesis.
  • Two groups received five minutes of EA at Neiguan (P6) using 1.0 Hz or 5.0 Hz stimulation.
  • A control group received no EA treatment.

Main Results:

  • Both 1.0 Hz and 5.0 Hz EA significantly reduced the number of emetic episodes (39% and 43% reduction, respectively, p < 0.05).

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  • EA treatment also significantly prolonged the onset time of emesis compared to the control group.
  • The ferret model demonstrated EA's effectiveness as an antiemetic.

    • Conclusions:

    • Electroacupuncture (EA) at Neiguan (P6) is an effective antiemetic intervention for morphine-induced emesis in ferrets.
    • This study supports EA as a potential therapeutic strategy and provides a model for further research into the mechanisms of acupuncture and emesis.