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Updated: Jul 21, 2026
10:22
Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
Published on: September 16, 2011
Popsicle-induced anaphylaxis due to carmine dye allergy
J L Baldwin1, A H Chou, W R Solomon
1Department of Internal Medicine, University of Michigan, Ann Arbor, USA.
Summary
Anaphylaxis after eating a carmine-colored popsicle was confirmed as IgE-mediated. Skin tests and a Prausnitz-Kustner test showed carmine-specific hypersensitivity.
Area of Science:
- Allergy and Immunology
- Food Science
- Toxicology
Background:
- Adverse reactions to carmine, a common food colorant, are suspected to be IgE-mediated hypersensitivity.
- This study investigates a case of anaphylaxis linked to carmine ingestion.
Observation:
- A patient experienced anaphylaxis following consumption of a carmine-colored popsicle.
- Skin prick tests revealed sensitivity to both the popsicle and carmine.
- Other popsicle ingredients did not trigger reactions.
Findings:
- A Prausnitz-Kustner test successfully transferred carmine-specific IgE antibodies, confirming an IgE-mediated reaction.
- Control subjects and the patient's husband showed no carmine sensitivity via skin prick tests.
- Topical application of carmine-containing cosmetics caused no immediate reaction.
Implications:
- This case provides strong evidence for carmine-specific IgE-mediated hypersensitivity causing anaphylaxis.
- Highlights the importance of identifying specific allergens in food-induced anaphylaxis.
- Suggests potential for carmine allergy in susceptible individuals.
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