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Related Experiment Videos

Significance of a false-positive trisomy 18 multiple-marker screening test

K D Wenstrom1, J Owen, C G Brumfield

  • 1Department of Obstetrics and Gynecology, University of Alabama at Birmingham, USA.

Obstetrics and Gynecology
|December 16, 1997
PubMed
Summary

A false-positive trisomy 18 screening test does not increase pregnancy complication risk. This result may stem from not adequately adjusting for maternal weight, suggesting improved screening accuracy with weight correction.

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Area of Science:

  • Prenatal Diagnosis
  • Maternal-Fetal Medicine
  • Genetics

Background:

  • Multiple-marker screening tests are used to assess the risk of fetal aneuploidies.
  • Trisomy 18 screening involves analyzing maternal serum markers like AFP, unconjugated estriol, and hCG.
  • False-positive results can cause anxiety and lead to unnecessary invasive procedures.

Purpose of the Study:

  • To investigate whether a false-positive trisomy 18 screening test is associated with increased obstetric complications.
  • To determine if maternal weight influences false-positive trisomy 18 screening results.

Main Methods:

  • Retrospective analysis of a genetic database including 3900 normal and 103 trisomy 18 positive screening tests.
  • Comparison of demographic and pregnancy outcome data between women with normal and false-positive screens.

Related Experiment Videos

  • Evaluation of the impact of maternal weight adjustment on screening accuracy.

    • Main Results:

    • False-positive trisomy 18 screens were associated with higher maternal weight and younger maternal age.
    • No increased risk for pregnancy complications was observed in women with false-positive screens.
    • Weight-adjusting all three analytes reduced the false-positive rate by 42% without affecting trisomy 18 detection.

    Conclusions:

    • False-positive trisomy 18 screening results do not predict adverse pregnancy outcomes.
    • Inadequate maternal weight correction may contribute to false-positive trisomy 18 screening results.
    • Implementing weight-adjusted algorithms for all analytes could improve screening specificity.