Is duodenal gastric metaplasia a consequence of Helicobacter pylori infection in children?

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Y Elitsur1, W E Triest

  • 1Department of Pediatrics, Cabell Huntington Hospital, Marshall University School of Medicine, Huntington, West Virginia 25701-0195, USA.

The American Journal of Gastroenterology
|December 17, 1997
PubMed

Insights

Duodenal gastric metaplasia (DGM) was found in 13% of pediatric patients. Duodenitis, not H. pylori infection, was linked to DGM in children, suggesting it

Area of Science:

  • Pediatric Gastroenterology
  • Histopathology
  • Microbiology

Background:

  • Duodenal gastric metaplasia (DGM) is linked to H. pylori (Hp) gastritis in adults and duodenal ulcers.
  • The prevalence and pediatric risk factors for DGM remain unclear.

Purpose of the Study:

  • To determine DGM prevalence in children.
  • To explore associations between DGM and age, gender, gastritis, duodenitis, or Hp presence.

Main Methods:

  • Retrospective analysis of 173 pediatric upper endoscopy procedures.
  • Biopsies stained for Hp, DGM, and general histology; inflammation graded by Sydney criteria.

Main Results:

  • DGM identified in 13% (23/173) of pediatric patients.
  • Duodenitis, but not age, gender, gastritis, or Hp presence, was associated with DGM.
  • Hp found in only 4 of 23 DGM foci.

Conclusions:

  • DGM in children is not a direct consequence of H. pylori infection.
  • Duodenitis is a potential risk factor for DGM in pediatric populations.
Abstract

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