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The PIR-International Protein Sequence Database

W C Barker1, J S Garavelli, D H Haft

  • 1Protein Information Resource, National Biomedical Research Foundation, 3900 Reservoir Road, NW, Washington, DC 20007, USA. pirmail@nbrf.georgetown.edu

Nucleic Acids Research
|February 21, 1998
PubMed
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The Protein Information Resource (PIR) database provides comprehensive protein sequence data, supporting evolutionary and computational biology research. It has been continuously updated and classified since 1984, ensuring data quality and accessibility.

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Evolutionary Biology

Background:

  • The Protein Information Resource (PIR) has a long history of supporting biological research.
  • Established in 1984, PIR has consistently provided a protein sequence database.
  • Since 1988, PIR-International has managed the database through collaborative efforts.

Purpose of the Study:

  • To provide a comprehensive, quality-controlled, and well-organized protein sequence database.
  • To support research in evolution and computational biology.
  • To ensure efficient data propagation and standardization through sequence classification.

Main Methods:

  • Compiling and maintaining a protein sequence database.
  • Regularly updating the database since 1984.

Related Experiment Videos

  • Classifying sequence entries into families for standardized annotation.

    • Main Results:

    • Essentially all sequence entries were classified into families by June 1997.
    • Facilitated efficient application of methods for annotation propagation and standardization.
    • Ensured a high-quality, organized protein sequence resource.

    Conclusions:

    • The PIR database is a valuable, continuously updated resource for biological research.
    • International collaboration enhances the development and maintenance of biological databases.
    • Data classification into families improves data utility and standardization.