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Small RNA database

J Gu1, Y Chen, R Reddy

  • 1Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA.

Nucleic Acids Research
|February 21, 1998
PubMed
Summary
This summary is machine-generated.

This study compiles over 600 small RNA sequences from diverse organisms, including eukaryotes, prokaryotes, and viruses. The database provides RNA sources and GenBank accession numbers, accessible online.

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Area of Science:

  • Bioinformatics
  • Molecular Biology
  • Genomics

Background:

  • Small RNAs play crucial roles in gene regulation across various life forms.
  • Existing databases may lack comprehensive collections of diverse small RNA sequences.
  • Efficient access to curated small RNA data is essential for research.

Purpose of the Study:

  • To create a centralized and accessible database of small RNA sequences.
  • To include small RNAs from eukaryotic, prokaryotic, and viral origins.
  • To provide essential metadata for each small RNA sequence.

Main Methods:

  • Compilation of publicly available small RNA sequences.
  • Annotation of RNA sources and GenBank accession numbers.
  • Development of a World Wide Web accessible interface.

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Main Results:

  • The database currently contains approximately 600 small RNA sequences.
  • Includes nuclear, nucleolar, cytoplasmic, and mitochondrial small RNAs from eukaryotes.
  • Incorporates small RNAs from prokaryotic cells and viruses.

Conclusions:

  • The Small RNA Database offers a valuable resource for researchers studying small RNAs.
  • Facilitates comparative genomics and functional studies of small RNAs.
  • The database is continuously updated with newly discovered small RNA sequences.