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The RNA modification database--1998

J A McCloskey1, P F Crain

  • 1Department of Medicinal Chemistry and Department of Biochemistry, 311A Skaggs Hall, University of Utah, Salt Lake City, UT 84112, USA.

Nucleic Acids Research
|February 21, 1998
PubMed
Summary
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This study details an updated RNA modification database, cataloging post-transcriptionally modified nucleosides from RNA. It offers comprehensive data on their occurrence, distribution, chemical properties, and literature references for researchers.

Area of Science:

  • Molecular Biology
  • Biochemistry
  • Bioinformatics

Background:

  • RNA modifications are crucial for gene expression regulation and cellular function.
  • A comprehensive resource for these modifications is essential for RNA research.
  • Previous work established a foundational printed report on modified nucleosides.

Purpose of the Study:

  • To provide an updated and comprehensive online database of post-transcriptionally modified nucleosides in RNA.
  • To consolidate information on RNA modifications, including their occurrence, distribution, and chemical characteristics.

Main Methods:

  • Compilation and curation of data from scientific literature, including the initial printed report.
  • Organization of information for each nucleoside, covering RNA type, phylogenetic distribution, chemical identity, and structure.

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  • Inclusion of literature citations for structural characterization, occurrence, and chemical synthesis.

    • Main Results:

    • A comprehensive listing of post-transcriptionally modified nucleosides from RNA.
    • Detailed information for each nucleoside, including common chemical name, symbol, Chemical Abstracts registry number, and chemical structure.
    • Accessible data through the World Wide Web at http://www-medlib.med.utah.edu/RNAmods/RNAmods.html.

    Conclusions:

    • The RNA modification database serves as a vital, updated resource for the scientific community.
    • It facilitates research by providing easy access to extensive data on RNA nucleoside modifications.
    • The database supports studies in molecular biology, biochemistry, and related fields.